Abstract
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Drug Discovery / methods*
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Epoxide Hydrolases / antagonists & inhibitors*
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Epoxide Hydrolases / metabolism*
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Humans
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Solubility
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Structure-Activity Relationship
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Urea / chemistry
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Urea / classification
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Urea / metabolism*
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Urea / pharmacology